Ptp2/Ptp3

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Contents 1 About Ptp2 2 About Ptp3 3 Reactions 4 Species Representation 4.1 Molecule Type 4.2 Model Seed

About Ptp2

• Ptp2 contains a putative MAPK-binding sequence at residues 208-220. Metodiev et al. 2002 PMID 12029138
• Ptp2 is nuclear. Mattison et al. 1999 PMID 10523653
• Ptp2 is a protein tyrosine phosphatase. Wurgler-Murphy et al. 1997 PMID 9032256

About Ptp3

• Ptp3 is cytoplasmic. Mattison et al. 1999 PMID 10523653

• Ptp3 is a protein tyrosine phosphatase. Wurgler-Murphy et al. 1997 PMID 9032256

• Ptp3 is found throughout the cytosol and nucleus, although it is slightly more concentrated in the cytosol. Maeder et al. 2007 PMID 17952059

• Ptp3 levels do not significantly change in response to pheromone. Maeder et al. 2007 PMID 17952059

Reactions

MAPK/phosphatase interactions
Ste12 mediated protein synthesis
Protein dilution/synthesis due to cell growth

Species Representation

Since we are not treating the cytoplasm and nucleus as deparate compartments, we will lump Ptp2 and Ptp3 together into one species, Ptp.

Molecule Type

Ptp(MAPK_site)

Model Seed

Ptp(MAPK_site) Ptp_tot_conc